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See Latest ArticlesEffectiveness of guaraná (Paullinia cupana) for postradiation fatigue and depression: results of a pilot double-blind randomized study
Journal of Alternative and Complementary Medicine, 04/29/09
da Costa Miranda V et al. - In a study to evaluate the effectiveness of guaraná in the treatment of postradiation depression and fatigue, the authors were unable to show any statistically significant differences between the guaraná and placebo-treated group with any of the measured scores. Within the same group, no statistically significant associations were seen during either the guaraná- or placebo-treated periods with any of the measures. There was no evidence that pts with breast cancer undergoing radiation therapy derive any advantage with guaraná over placebo for fatigue and depressive symptoms.
Methods- A trial was done with 36 pts with breast cancer undergoing adjuvant radiation therapy.
- Pts were randomized to either guaraná 75 mg daily p.o. or to placebo.
- Pts were switched to the other experimental arm at the middle of radiation treatment, which consisted of 28 daily fractions of 180 cGy.
- Evaluations were conducted at the beginning, middle, and end of radiation therapy.
- There were no statistically significant differences between the guaraná and the placebo-treated group with any of the measured scores.
- Within the same group, there were no statistically significant associations during either the guaraná- or placebo-treated periods with any of the aforementioned measures.
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