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Pralatrexate-induced tumor cell apoptosis in the epidermis of a patient with HTLV-1 adult T-cell lymphoma/leukemia (ATLL) causing skin erosions
Blood, 04/27/09
Marneros AG et al. - Here authors present in vivo evidence that pralatrexate-induced erosions in skin affected by ATLL are a manifestation of apoptosis of tumor cells infiltrating the epidermis and are not due to cytotoxicity by pralatrexate on keratinocytes. This distinction is critical and may profoundly influence the clinical decision to continue pralatrexate treatment. Pralatrexate-induced skin erosions may indicate response to treatment.
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