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See Latest ArticlesMatriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis
Haematologica, 04/23/09
Ramsay AJ et al. - 14 patients with iron-refractory iron deficiency anemia (IRIDA) have been reported to harbor various genetic mutations that abrogate matriptase-2 proteolytic activity. In this review, after overviewing the membrane anchored serine proteases, in particular the TTSP family, the authors summarize the identification and characterization of matriptase-2 and describe its functional relevance in iron metabolism.
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