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Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma
Cancer Science, 04/20/09
Morioka K et al. - The authors identified wingless-type MMTV integration site family, member 5B (WNT5B) as a putative ROR2 ligand and that the physiological interaction of WNT5B and ROR2 could enhance cell migration, indicating the possible roles of ROR2 and WNT5B in the metastatic property of osteosarcoma cells. Taken together, findings revealed that the WNT5B/ROR2 signaling pathway is a promising therapeutic target for osteosarcoma.
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