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See Latest ArticlesABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma
Leukemia and Lymphoma, 04/21/09
Drain S et al. - In a study to estimate the frequency of a single nucleotide polymorphism (SNP) within ABCB1, rs1045642 (C3435T), in the Northern Irish population and investigate its impact on the overall survival (OS) of pts with plasma cell myeloma (PCM), it was shown that findings within the PCM cohort suggest that rs1045642 genotype influence OS.
Methods- Multi-drug resistance (MDR) may compromise successful management of haematological malignancies, impairing the effectiveness of chemotherapy.
- P-glycoprotein (P-gp) drug efflux pump, encoded by the gene ABCB1 (MDR1), is the most widely studied component in MDR.
- An SNP has been identified within ABCB1, rs1045642 (C3435T), which may alter P-gp substrate specificity and have an impact on the effectiveness of treatment, and hence OS.
- There was no significant difference in the frequency of rs1045642 between the PCM cohort and an age- and gender-matched control population.
- Findings within the PCM cohort suggest that rs1045642 genotype influences OS.
- These results suggest that genotyping rs1045642 may be a useful predictor of outcome in PCM and could indicate modified treatment modalities in certain individuals.
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