Oncology Medical News about HRT;obesity;poor breast cancer prognosis

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Obesity and poor breast cancer prognosis: an illusion because of hormone replacement therapy?
British Journal of Cancer, 04/16/09

Rosenberg L et al. - In a study to investigate the influence of body mass index (BMI) and hormone replacement therapy (HRT) on breast cancer prognosis, it was shown that influence of BMI on breast cancer prognosis was similar whether diagnosed by mammographic screening or not. Similar prognosis of postmenopausal breast cancer-specific death was found regardless of BMI in non-users of HRT, but among HRT users obesity was associated with a poorer breast cancer prognosis.

Methods

We The influence of BMI and HRT on prognosis was investigated in 2640 postmenopausal women diagnosed with breast cancer, taking into account HRT and mammography before diagnosis.
Logistic and Cox regression were used.

Results

In non-users of HRT, obese women (BMI >30) compared with normal weight women (BMI <25) had a similar prognosis, despite larger tumours found in obese women.
Obese HRT users had less favourable tumour characteristics and poorer prognosis compared with normal weight women.

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