Oncology Medical News about intraductal papillary mucinous neoplasms of the pancreas;hypermethylation-mediated reduction of WWOX expression

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Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas
British Journal of Cancer, 04/09/09

Nakayama S et al. - In a trial to examine WW domain-containing oxidoreductase (WWOX) expression in intraductal papillary mucinous neoplasm of the pancreas (IPMN) to assess the function of WWOX in pancreatic duct tumourigenesis, it was reported that downregulation of WWOX expression by the WWOX regulatory region hypermethylation is critical for transformation of pancreatic duct.

Methods

WWOX expression was examined in IPMN to assess the function of WWOX in pancreatic duct tumourigenesis using immunohistochemistry and methylation-specific polymerase chain reaction analysis.

Results

Among 41 IPMNs including intraductal papillary mucinous adenomas (IPMAs) and intraductal papillary mucinous carcinomas (IPMCs), loss or reduced WWOX immunoreactivity was detected in 3 (15%) of 20 IPMAs and 17 (81%) of 21 IPMCs.
Hypermethylation of the WWOX regulatory site was detected in 1 (33%) of 3 WWOX(-) IPMAs and 9 (53%) of 17 WWOX(-) IPMCs, suggesting that hypermethylation may be important in suppression of WWOX expression.
Reduction of WWOX expression was significantly correlated with a higher Ki-67 labelling index but was not correlated with the ssDNA apoptotic body index.
Decreased WWOX expression was significantly correlated with loss of SMAD4 expression in these IPMNs.

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