Oncology Medical News about brain tumor formation;curcumin

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Curcumin blocks brain tumor formation
Brain Research, 04/07/09

Purkayastha S et al. – Solubilized curcumin effectively blocks brain tumor formation and also eliminates brain tumor cells. Thus, judicious application of such injectable formulations of curcumin may be a safe therapeutic strategy for treating brain tumors.

Methods

Assessment of a soluble formulation of curcumin in brain tumor formation
Study of the mechanism of action in vitro

Results

Curcumin crosses the blood–brain barrier but does not suppress normal brain cell viability
Tail vein injection, or more effectively, intracerebral injection through a cannula, blocks brain tumor formation in mice that had intracerebral bolus of mouse melanoma cells (B16F10)
Solubilized curcumin causes activation of proapoptotic enzymes caspase 3/7 in human oligodendroglioma (HOG) and lung carcinoma (A549) cells, and mouse tumor cells N18 (neuroblastoma), GL261 (glioma), and B16F10
MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assays show simultaneous decrease in cell viability
Study of B16F10 cells showed that curcumin effectively suppresses cyclin D1, P-NF-kB, BclXL, P-Akt, and VEGF, which explains its efficacy in blocking proliferation, survival, and invasion of B16F10 cells in brain

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