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Curcumin blocks brain tumor formation
Brain Research, 04/07/09

Purkayastha S et al. – Solubilized curcumin effectively blocks brain tumor formation and also eliminates brain tumor cells. Thus, judicious application of such injectable formulations of curcumin may be a safe therapeutic strategy for treating brain tumors.

• Assessment of a soluble formulation of curcumin in brain tumor formation
• Study of the mechanism of action in vitro

• Curcumin crosses the blood–brain barrier but does not suppress normal brain cell viability
• Tail vein injection, or more effectively, intracerebral injection through a cannula, blocks brain tumor formation in mice that had intracerebral bolus of mouse melanoma cells (B16F10)
• Solubilized curcumin causes activation of proapoptotic enzymes caspase 3/7 in human oligodendroglioma (HOG) and lung carcinoma (A549) cells, and mouse tumor cells N18 (neuroblastoma), GL261 (glioma), and B16F10
• MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assays show simultaneous decrease in cell viability
• Study of B16F10 cells showed that curcumin effectively suppresses cyclin D1, P-NF-kB, BclXL, P-Akt, and VEGF, which explains its efficacy in blocking proliferation, survival, and invasion of B16F10 cells in brain

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