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Expression of Ezrin correlates with lung metastasis in Chinese patients with osteosarcoma
Clinical and Investigative Medicine, 04/07/09

Xu-dong S et al. - In a study to determine the prognostic value of the expression of Ezrin, CD44, and Six1 genes in osteosarcoma tissues of Chinese pts, the data suggest that Ezrin, but not CD44 and Six1, could be a prognostic factor and a predictor of potential lung metastasis in osteosarcoma.

Methods

Fluorescent quantitative real-time PCR was applied to study mRNA levels of Ezrin, CD44, and Six1 genes in 32 osteosarcoma pt samples and 10 adjacent normal tissues and MG63 osteosarcoma cell lines.
Analysis of relationships between pulmonary metastasis and overall survival (OS) time were carried out based on the clinical data.

Results

mRNA levels of Ezrin and Six1 genes in osteosarcoma tissues were higher than those in adjacent normal tissues.
mRNA levels of Ezrin, CD44, and Six1 genes were closely correlated with Enneking GTM clinical staging, while no correlations were demonstrated between mRNA level of the genes with sex, age, location or pathological types.
High mRNA level of Ezrin gene was related to shorter lung metastasis-free and OS time of Chinese pts with osteosarcoma.

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