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See Latest ArticlesBone-Resorbing Cells in Multiple Myeloma: Osteoclasts, Myeloma Cell Polykaryons, or Both
The Oncologist, 04/03/09
Silvestris F et al. - The possibility that myeloma cells fuse and generate polykaryons in vivo is suggested by the in vitro formation of multinuclear cells that express tartrate-resistant acid phosphatase and produce pits and erosive lacunae on experimental osteologic substrates. Further, the detection in vivo of polykaryons with chromosome translocations typical of myeloma cells lends support to the view that myeloma polykaryons may act as functional OCs and participate in the skeletal destruction by resorbing bone.
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Today in Bone/Cartilage...keeping you current
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mTOR/p70S6K Signal transduction pathway contributes to osteosarcoma progression and patients prognosis
Medical Oncology, 12/04/09
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