Oncology Medical News about Prostate Cancer; Rye

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Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer
The Journal of Nutrition, 04/15/09

Landberg R et al. - In a study to determine the short- to medium-term reproducibility of plasma alkylresorcinols (AR) in men with prostate cancer (PCa), results show that a single fasting plasma sample could be used to estimate the mean plasma AR concentration during a 6-wk intervention period with constant intake at a precision of ± 20% (80% CI). The plasma AR concentration can be used as a reliable short- to medium-term biomarker for whole-grain wheat and rye under intervention conditions where intake is kept constant.

Methods

Short- to medium-term reproducibility of plasma AR was determined using samples from a crossover intervention study, where men with PCa (n = 17) were fed rye whole-grain/bran or refined wheat products for 6-wk periods.

Results

AR homologs C17:0 and C21:0 differed between the treatments.
Reproducibility determined by the intraclass correlation coefficient (ICC) was high (intervention period 1: ICC = 0.90, intervention period 2: ICC = 0.88).

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