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See Latest ArticlesIncreased prevalence of insulin resistance in patients with differentiated thyroid carcinoma
Metabolic Syndrome and Related Disorders, 03/31/09
Rezzónico JN et al. - In a study to determine whether patients with differentiated thyroid carcinoma (DTC) also have a higher frequency of insulin resistance (IR), it was found that such a high prevalence of IR would be an important risk factor for developing DTC, as it is well known with some other nonthyroid carcinomas.
Methods- 20 women with DTC (group 1, G1) and 20 euthyroid individuals (control group, CG) were investigated for IR.
- G1 and CG subjects were matched in pairs by age, gender, and body mass index (BMI).
- Diagnosis of IR was made when the homeostasis model assessment of insulin resistance (HOMA-IR) index was higher than 2.5.
- According to BMI, 20 women (10 with DTC and 10 of the CG) had a BMI <25, whereas the other 20 had higher BMI values (overweight and obese pts).
- IR was present in the 50% of G1, but only in the 10% of CG.
- In groups with lower BMI (<25), IR was found in 30% of G1 and no cases in the CG, whereas in those with BMI >25 the IR was present in 70% of G1 and 20% of CG.
- There were no differences between the 2 subgroups regarding the time in which the IR tests were performed.
- IR was present in 56.3% of pt with papillary and 25% of follicular thyroid carcinomas, respectively.
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