Oncology Medical News about Panax ginseng; Chemopreventive effect

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Chemopreventive effect of Panax ginseng
Phytotherapy Research, 03/20/09

Varjas T et al. - In a study to evaluate the chemo-preventive effects of Asian ginseng in an animal test model, through its regulatory effects on apoptosis and the cell cycle, these results support the efficacy of ginseng-containing diets and dietary supplements in the prevention of cancerous diseases.

Methods

Expression of genes (Bcl-2, Bcl-x and Cyclin D1) which affect apoptosis were examined, in different organs of animals which had consumed a ginseng-containing diet in the presence of a known carcinogen (DMBA).
Pattern of gene expression was determined by Q-RT-PCR.

Results

Research has shown that it is possible to interfere with the multi-step process of carcinogenesis through the use of compounds with chemo-preventive effects, such as the inhibition of the activation of antiapoptotic genes.
Increase of antiapoptotic gene expression after carcinogenic exposure was suppressed by consumption of ginseng which promoted apoptosis.

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