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Effects of Food on the Relative Bioavailability of Lapatinib in Cancer Patients
Journal of Clinical Oncology, 03/13/09
Koch KM et al. - These large increases in lapatinib bioavailability and absolute variability support the recommendation for dosing in the fasted state to achieve consistent therapeutic exposure. Prescribers and patients should consider the potential consequences of toxicity or diminished efficacy that might result from dosing without regard to variations in diet.
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