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See Latest ArticlesEpigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
Carcinogenesis, 03/09/09
Marsit CJ et al. - Although there was a significant association between methylation profile and tumor stage, authors did not observe an association between these profiles and overall patient survival after adjustment for stage; although methylation of a number of specific loci falling in different cellular pathways was associated with overall patient survival. They found that the etiologic heterogeneity of HNSCC is reflected in specific patterns of molecular epigenetic alterations within the tumors and that the DNA methylation profiles may hold clinical promise worthy of further study.
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