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See Latest ArticlesFungating soft-tissue sarcomas
Journal of Bone and Joint Surgery, 03/09/09
Potter BK et al. - Malignant tumor ulceration is an independent predictor of a poor prognosis for patients with a high-grade soft-tissue sarcoma. Despite the discouraging overall prognosis, aggressive multidisciplinary treatment can lead to long-term survival in an important subgroup of patients with fungating lesions.
Methods- Study to evaluate the treatment or prognosis of fungating soft-tissue sarcomas
- 24 pts with a primary high-grade fungating tumor; 146 consecutive pts with a primary high-grade non-fungating tumor were controls
- Study cohorts were compared with regard to disease presentation, treatment, and oncologic outcomes
- No significant differences in tumor size, tumor depth, or histopathologic diagnoses between the cohorts
- Although pts with a fungating tumor tended to be older and have shorter postoperative f/u
- Proportion of pts presenting with metastases was greater in the group with a fungating tumor
- More pts with a fungating tumor underwent amputation, while a greater proportion of control pts received radiation therapy
- No difference in the proportions of pts receiving chemotherapy or in the local recurrence rates between the two cohorts
- 5-yr OS estimates were 20% in the group with a fungating tumor vs 63% in control group
- 5-yr disease-specific survival estimates for pts presenting with localized disease was 58% in the group with a fungating tumor and 74% in the control group
- Disease stage, fungation, and a tumor size of ≥10 cm were independent negative prognostic factors for disease-specific survival
Today in Soft Tissue/Sarcoma...keeping you current
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