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See Latest ArticlesLong-term use of β-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study
American Journal of Epidemiology, 02/19/09
Satia JA et al. - In a study to assess the long-term use of high-dose ?-carotene supplementation in the general population, it was shown that long-term use of individual β-carotene, retinol, and lutein supplements should not be recommended for lung cancer prevention, particularly among smokers.
Methods- Associations of supplemental β-carotene, retinol, vitamin A, lutein, and lycopene with lung cancer risk were examined among participants, aged 50–76 years.
- In 2000–2002, eligible persons (n = 77,126) completed a 24-page baseline questionnaire, including detailed questions about supplement use during the previous 10 yrs from multivitamins and individual supplements/mixtures.
- 521 incident lung cancers through December 2005 were identified by linkage to the SEER cancer registry.
- Longer duration of use of individual β-carotene, retinol, and lutein supplements was associated with statistically significantly elevated risk of total lung cancer and histologic cell types.
- There was little evidence for effect modification by gender or smoking status.
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