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Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia
Annals of Hematology, 01/30/09
Schwarz A et al. - Plasma DNA was higher in children with ALL at diagnosis but returned to normal within the first four treatment days. Despite low concentrations of DNA, it is feasible to measure MRD kinetics in plasma DNA during ALL induction therapy by adapted real-time PCR methodologies.
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