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See Latest ArticlesIn vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients
Phytotherapy Research, 01/29/09
Engdal S et al. - In a study to investigate the herbal remedies Natto K2, Agaricus, mistletoe, noni juice, green tea and garlic, frequently used by cancer pts for their in vitro inhibition potential of cytochrome P-450 3A4 (CYP3A4) metabolism, it seems that although Agaricus, noni juice, mistletoe and green tea inhibited CYP3A4 metabolism in vitro, clinically relevant systemic or intestinal interactions with CYP3A4 were considered unlikely, except for a probable inhibition of intestinal CYP3A4 by the green tea product.
Methods- Metabolic studies were performed with human c-DNA baculovirus expressed CYP3A4.
- Testosterone was used as a substrate and ketoconazole as a positive quantitative inhibition control.
- Formation of 6-β-OH-testosterone was quantified by a validated HPLC methodology.
- Green tea was the most potent inhibitor of CYP3A4 metabolism, followed by Agaricus, mistletoe and noni juice.
- All IC50 values were high compared with those determined for crude extracts of other herbal remedies.
- IC50/IC25 ratios for the inhibiting herbal remedies ranged from 2.15 to 2.67, indicating similar inhibition profiles of the herbal inhibitors of CYP3A4.
- Garlic and Natto K2 were classified as non-inhibitors.
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