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Mulabagal V et al. - Both S-containing dimeric withanolides, 1 and 2, completely suppressed TNF-induced NF-kB activation when tested at 100 mum. The isolation of a withanolide sulfoxide from W. somnifera roots and its ability to inhibit COX-2 enzyme and to suppress human tumor cell proliferation are reported here for the first time. In addition, this is the first report on the abrogation of TNF-induced NF-kB


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