Oncology Medical News about chemo-induced DNA fragmentation;Carnosol

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Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells
Nutrition and Cancer, 01/12/09

Zunino SJ et al. – Findings show that carnosol (from the herb rosemary) blocks terminal apoptotic events induced by chemotherapeutic drugs and suggest that increased dietary carnosol may decrease effectiveness of some standard chemotherapy treatments used for leukemia.

Methods

Study of carnosol for its ability to sensitize leukemia cells to chemotherapeutic agents
Analysis of DNA strand breaks by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling
Time course analysis of caspase-3 activation by flow cytometry

Results

Carnosol reduced cell death in the pre-B acute lymphoblastic leukemia (ALL) lines SEM, RS4;11, and REH when combined with cytarabine, methotrexate, or vincristine vs chemotherapeutic agents alone
Carnosol delayed DNA cleavage when combined with chemotherapeutic drugs
Co-treatment of cells with carnosol and chemotherapeutic drugs did not reduce mitochondrial membrane depolarization vs drug treatment alone
Cotreatment with carnosol and drugs increased activation of caspase-3 vs chemotherapeutic drugs alone
Fewer caspase-3 positive cells progressed to an apoptotic phenotype when co-treated with carnosol and chemotherapeutic drugs vs drugs alone

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