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Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells
Biochemical and Biophysical Research Communications, 01/12/09

Lin YJ et al. – Data suggest that Puerariae radix (PR; a popular natural herb and a traditional food in Asia) may act as a chemopreventive and/or chemotherapeutic agent against breast cancer by reducing cell viability and inducing apoptosis.

• Study to investigate the effects of PR isoflavones puerarin, daidzein, and genistein on the growth of BCa cells

• PR isoflavones treatment led to dose-dependent inhibition of cell growth in HS578T, MDA-MB-231, and MCF-7 cell lines
• PR isoflavones also induced cell apoptosis through a caspase-3-dependent pathway; mediated cell cycle arrest in the G2/M phase
• Serum metabolites of PR (daidzein sulfates/glucuronides) inhibited proliferation of the BCa cells with GI₅₀ of 2.35 µM
• This suggested that daidzein constituent of PR can be metabolized to daidzein sulfates or daidzein glucuronides that exhibit anticancer activities
• Protein expression levels of the active forms of caspase-9 and Bax were increased by treatment with PR metabolites
• These metabolites also increased the protein expression levels of p53 and p21

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