Oncology Medical News about prostate cancer;Selenium and Vitamin E

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Review of prostate cancer prevention study shows no benefit for use of selenium and vitamin E supplements
National Cancer Institute, 12/23/08

Lippman SM et al. - In a study to assess the use of selenium and vitamin E supplements in prevention of prostate cancer, it was shown that selenium and vitamin E supplements, taken either alone or together, did not prevent prostate cancer.

Methods

Men were randomly assigned to take 1 of 4 sets of supplements or placebos, with more than 8000 men in each group.
One group took both selenium and vitamin E; one took selenium and a vitamin E placebo; one took vitamin E and a selenium placebo; and the final group received placebos of both supplements.

Results

5-year rate of prostate cancer diagnosis in the 4 arms of the study was 4.43% in the placebo arm, 4.56% in the selenium arm, 4.93% in the vitamin E arm (the highest rate, not a statistically significant difference from the placebo arm), and 4.56% in the selenium plus vitamin E arm.
There was a small but not statistically significant increase in the number of prostate cancer cases among the over 35,000 men age 50 and older in the trial taking only vitamin E.
There was a small, but not statistically significant, increase in the number of cases of adult-onset diabetes in men taking only selenium (10% for those taking selenium vs 9.3% taking placebo).

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