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Managing symptoms among patients with breast cancer during chemotherapy: Results of a two-arm behavioral trial
Journal of Clinical Oncology, 12/23/08

Given CW et al. – For metastatic disease pts, an educational information intervention via an automated voice response system to assess symptoms and refer pts to a Symptom Management Guide is more effective for greater symptom responses in a shorter time than a complex cognitive behavioral approach.

Methods

Study to compare symptom response and times to response for breast cancer pt subset
Pts assigned to either cognitive-behavioral Nurse-Administered Symptom Management intervention or Automated Telephone Symptom Management (ATSM) intervention
Baseline equivalence between arms; no differential attrition by arm
Anchor-based definition of response: mild, moderate, and severe categories of symptom severity
Asessment of responses and times to response for 15 symptoms in relation to trial arm, comorbid conditions, treatment protocols, and metastatic vs localized disease

Results

ATSM arm more effective among pts with metastatic disease
Greater response and shorter time to response for pts treated with single agents vs combination chemotherapy protocols

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