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Lippman SM et al. – Selenium or vitamin E, alone or in combination, did not prevent prostate cancer in a population of relatively healthy men.
Methods- Study of whether selenium, vitamin E, or both could prevent prostate cancer and other diseases with little or no toxicity in relatively healthy men
- Selenium and Vitamin E Cancer Prevention Trial (SELECT): randomized, placebo-controlled, double-blind trial of 35,533 men from 427 sites in US, Canada, Puerto Rico from August 22, 2001, to June 24, 2004
- Randomization to 4 groups: selenium, vitamin E, selenium + vitamin E, placebo
- Baseline eligibility: age ≥50 yrs (African American men) or ≥55 yrs (all other men), serum PSA ≤4 ng/mL, and a digital rectal examination not suspicious for prostate cancer
- Main outcome measures: prostate cancer
- Secondary outcomes: lung, colorectal, overall primary cancer
- Median overall follow-up: 5.4
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