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Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial
JAMA, 11/07/08

Zhang SM et al. - In a trial to evaluate the effect of combined folic acid, vitamin B6, and vitamin B12 treatment on cancer risk in women at high risk for cardiovascular disease, it seems that combined folic acid, vitamin B6, and vitamin B12 treatment had no significant effect on overall risk of total invasive cancer or breast cancer among women during the folic acid fortification era.

Methods

5442 US female health professionals aged 42 yrs or older, with preexisting cardiovascular disease or 3 or more coronary risk factors, were randomly assigned to receive either a daily combination of folic acid, vitamin B6, and vitamin B12 or a matching placebo.
They were treated for 7.3 yrs.
Daily supplementation of a combination of 2.5 mg of folic acid, 50 mg of vitamin B6, and 1 mg of vitamin B12 (n = 2721) or placebo (n = 2721).

Results

379 women developed invasive cancer: 187 in the active treatment group and 192 in the placebo group.
Compared with placebo, women receiving the active treatment had similar risk of developing total invasive cancer, breast cancer, or any cancer death.

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