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See Latest ArticlesPhase I clinical trial of i.v. ascorbic acid in advanced malignancy
Annals of Oncology, 10/30/08
Hoffer LJ et al. - In a study to assess the use of i.v. ascorbic acid in pts with advanced malignancies, it was found that high-dose i.v. ascorbic acid was well tolerated but failed to demonstrate anticancer activity when administered to pts with previously treated advanced malignancies. The promise of this approach may lie in combination with cytotoxic or other redox-active molecules
Methods- Pts with advanced cancer or hematologic malignancy were assigned to sequential cohorts infused with 0.4, 0.6, 0.9 and 1.5 g ascorbic acid/kg body weight 3 times weekly
- Adverse events and toxicity were minimal at all dose levels
- No pt had an objective anticancer response
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