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See Latest ArticlesPredictors of level V metastasis in well-differentiated thyroid cancer
Head & Neck, 09/03/08
Kupferman ME et al. - In a study to identify clinical and pathological predictors of cervical node metastases to level V in differentiated thyroid carcinoma, it was found that cervical metastases from differentiated thyroid carcinoma were commonly present at level V. Pts with multifocal cancer within the thyroid gland and cervical metastases in the ipsilateral jugular nodes have a higher risk of harboring metastatic disease at level V. Routine dissection of level V lymph nodes should be performed in the setting of a comprehensive neck dissection for pts with lateral neck metastasis from well-differentiated thyroid cancer
Methods- 70 pts who underwent thyroidectomy and neck dissection for well-differentiated thyroid cancer were retrospectively analyzed
- 53% of neck specimens harbored metastatic thyroid carcinoma at level V
- 13 level V contralateral neck dissections were performed, and 57% were found positive for metastases
- Presence of ipsilateral level V metastases was significantly associated with multifocal disease, ipsilateral level II, III, or IV metastases
- Ipsilateral involvement of level V was associated with contralateral lymph node metastases
- Age, sex, and size of primary tumor were not associated with level V metastases
- Preoperative imaging was not sensitive for detecting presence of level V metastases
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