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PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma
Oncogene, 08/06/08
Taniguchi E et al. - Inhibition of PDGFR-A by RNA interference, small molecule inhibitor or neutralizing antibody had a dramatic effect on tumor cell growth both in vitro and in vivo, although resistance evolved in one-third of tumors. These results establish proof-of-principal for PDGFR-A as a therapeutic target in alveolar rhabdomyosarcoma.
Today in Basic Science/Genetics...keeping you current
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Endocellular polyamine availability modulates epithelial-to-mesenchymal transition and unfolded protein response in MDCK cells
Laboratory Investigation, 03/19/10
Functional significance of the two ACOX1 isoforms and their crosstalks with PPAR[alpha] and RXR[alpha]
Laboratory Investigation, 03/19/10
Protein pathway biomarker analysis of human cancer reveals requirement for upfront cellular-enrichment processing
Laboratory Investigation, 03/19/10
Today in Soft Tissue/Sarcoma...keeping you current
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S-MED: Sarcoma microRNA Expression Database
Laboratory Investigation, 03/19/10
Primary Ewings sarcoma/primitive neuroectodermal tumor of the kidney that responded to low-dose chemotherapy with ifosfamide, etoposide, and doxorubicin
International Journal of Clinical Oncology, 03/19/10
Protection from Rapamycin-Induced Apoptosis by Insulin-Like Growth Factor-I Is Partially Dependent on Protein Kinase C Signaling
Cancer Research, 03/19/10
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