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RASSF1A interacts with and activates the mitotic kinase Aurora-A
Oncogene, 07/22/08
Print     Email This Article     Save in My Library   Free Abstract
Liu L et al. - The failure of recombinant RASSF1A to activate recombinant Aurora-A indicates that RASSF1A may not activate Aurora-A directly and suggests that RASSF1A may function as a scaffold to bring together Aurora-A and its activator(s). Inhibition of centrosome separation by RASSF1A overexpression is most likely a consequence of hyperstabilization of microtubules by this protein.
 

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