Machtay M et al. – For severe late toxicity after concurrent chemoradiotherapy (CCRT) strong independent risk factors are older age, advanced T-stage, and larynx/hypopharynx primary site; neck dissection after CCRT was associated with an increased risk of complications Methods
Study of clinical factors associated severe late toxicity after CCRT
Review of pts from a subset of 3 previously reported Radiation Therapy Oncology Group (RTOG) trials of CCRT for locally advanced squamous cell carcinoma of the head and neck (SCCHN)
Severe late toxicity defined as chronic grade 3 to 4 pharyngeal/laryngeal toxicity and/or feeding tube requirement ;gE>2 yrs after registration and/or potential treatment-related death (eg, pneumonia) within 3 yrs
Case-control analysis with multivariable logistic regression model including pretreatment and treatment potential factors
Results
Of 230 assessable pts, 131 were controls and 99 (43%) had severe late toxicities
On multivariable analysis, significant variables correlated with severe late toxicity: older age; advanced T stage; larynx/hypopharynx primary site; and neck dissection after CRT
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