Liu FT et al. - This data indicates that dietary flavonoids limit the efficacy of Bortezomib, while supplemental inorganic boric acid is able to reverse this, which means caution is required when giving dietary advice to patients. Methods
Aim was to study the activity of Bortezomib in the presence of dietary flavonoids in chronic lymphocytic leukemia (CLL)
Results
Killing activity of Bortezomib was blocked when cultured in 50% fresh autologous plasma that contains dietary flavonoids, quercetin and myricetin
This inhibitory effect was associated with chemical reactions between quercetin and the boronic acid group, -RB(OH)2, in Bortezomib
The addition of boric acid diminished the inhibitory effect of both quercetin and plasma on Bortezomib-induced apoptosis
The protective effect was also reduced when myeloma cell lines, but not B-cell lines, were pre-incubated with quercetin
At high doses, quercetin itself induced tumor cell death
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