Diergaarde B et al. - These results support the hypothesis that specific polymorphisms in genes involved in sex hormone metabolism may modify the effect of estrogen plus progestin (E+P) use on breast cancer risk. Methods
Study to evaluate the associations of common polymorphisms in genes involved in estrogen and/or progesterone metabolism, E+P use, and their interactions with BCa risk
A case-control study of postmenopausal women (324 cases; 651 controls)
Results
None of the polymorphisms studied was, by itself associated with BCa risk
E+P use was associated with increased BCa risk
Interactions between CYP1A1 Ile462Val, CYP1A1 MspI, CYP1B1 Val432Leu, CYP1B1 Asn453Ser, and PGR Val660Leu, and E+P use were observed
The risk was greater among women with at least one rare allele of the CYP1A1 and PGR polymorphisms vs those homozygous for the common allele of these polymorphisms
Risk of BCa increased little with increasing yrs of E+P use among women with at least one CYP1B1 Val432 allele
A large increase in risk was seen among women homozygous for CYP1B1 Leu432
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