O'Shea D et al. - In a study to investigate the prognostic value of TP53 mutation at diagnosis in follicular lymphoma (FL), it was found that molecular features of the malignant cell may correlate with the nature of the immune response in FL Methods
As TP53 mutations are associated with poor prognosis in hematological malignancies, the prognostic value of TP53 mutation was investigated in the diagnosis of FL
Results
Heterozygous TP53 mutation was detected in 12/185 analyzed cases
Mutation was associated with older age and higher IPI score
On multivariate analysis, TP53 mutation correlated with shorter progression-free and overall survival
TP53 mutation was associated with low expression of the immune-response 1 gene expression signature and with an unfavorable gene expression-based survival predictor score
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