Dunnwald LK et al. – Pts with locally advanced breast carcinoma (LABC) with limited or no decline in blood flow (BF) and [18F]fluorodeoxyglucose transport (FDG K1) had higher recurrence and mortality risks greater than the effects of clinical tumor characteristics; tumor perfusion changes over the course of neoadjuvant chemotherapy measured directly by [15O]water or indirectly by dynamic FDG predict DFS and OS Methods
Study of serial quantitative PET tumor BF and metabolism as in vivo measurements to predict pt outcome
Dynamic FDG and [15O]water PET scans before and at midpoint of neoadjuvant chemotherapy for 53 women with primary LABC
Calculatation of FDG metabolic rate (MRFDG) and transport (FDG K1) parameters
Estimation of BF from [15O]water study
Cox proportional hazards model of associations between BF, MRFDG, FDG K1, and SUV and disease-free survival (DFS) and overall survival (OS)
Results
Recurrence and mortality risks higher in pts with persistent or elevated BF and FDG K1 from baseline to midtherapy vs pts with reductions
In multivariable analyses, BF and FDG K1 changes remained independent prognosticators of DFS and OS
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