Idbaih A et al. - In a study to investigate a series of 16 low-grade gliomas (LGGs) and their subsequent progression to higher-grade malignancies, it seems that putative novel candidate genes associated with glioma progression were identified, in particular DOCK8, PTPRD, CER1, TPHO, DHFR, MSH3, ETS1, ACACA, and CSE1L Methods
Using a 1-megabase BAC-based array comparative genomic hybridization technique (aCGH), a series of 16 LGGs and their subsequent progression to higher-grade malignancies were investigated
Results
Most frequent chromosome imbalances in primary tumors were gains of chromosomes 7q, 8q, and 22q, and losses of chromosomes 1p, 13q, and 19q
In tumor progression, gains of chromosomes 11q, 7q, 20q, and 21q, and losses of chromosomes 9p, including CDKN2A locus, 19q, 14q, 1p, and 6q were the most frequent genomic disequilibria
Progressive tumors were more imbalanced than primary tumors in terms of altered chromosomal arms and altered BACs
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