Auer D et al. – A previously undescribed association between estrogen receptivity and the expression of transmembrane coxsackie-adenovirus receptor (hCAR) in breast cancer reflects a phenotype of low malignancy; hCAR expression may also be directly influenced by ER-specific ligands Methods
Study of the relationship between CAR expression (transmembrane and soluble isoforms) and hormone sensitivity in 95 breast cancers
Investigation of prognostic significance of expression of various CAR isoforms
Assessment of inducibility of CAR expression by estradiol and tamoxifen in various breast cancer cell lines
Results
Expression of transmembrane CAR (hCAR) highly correlated with estrogen receptivity, but was independent of progesterone receptor (PR) expression
hCAR expression significantly higher in low-grade tumors
No relationship between hCAR expression and tumor size, lymph node status, or survival
Estradiol and tamoxifen treatment increased hCAR and soluble isoform expression in hormone receptor-positive but not –negative breast cancer cell line T47-D
Enhanced hCAR expression was significantly greater for cells treated with histone deacetylase (HDAC) inhibitor trichostatin A (TSA) vs estradiol or tamoxifen
Sensitivity to TSA induction of hCAR was greater in receptor-positive vs -negative cell lines
No additive effect on CAR expression noted for TSA combined with either estradiol or tamoxifen
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