Orlando FA et al. – A review article of colorectal cancer progression discusses its origination from accumulated genetic and epigenetic alterations causing genomic instability and a malignant phenotype; subsequent molecular pathway deregulation leading to aberrant crypt foci (ACF) is reviewed; also discussed is genetic profiling using genomic instability, loss of heterozygosity, and methylation analysis showing minority population of ACF genotypically analogous to cancer
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