Takeshita M et al. – Aberrant expression of Aurora-A and/or of CHFR contributed to the increase in the malignant potential of nonsmall-cell lung cancer (NSCLC); CHFR expression was predominantly impaired in smoking-related squamous cell carcinoma and might be a useful prognostic marker in NSCLC Methods
Study of immunohistochemical protein expression of CHFR and Aurora-A in 157 NSCLC cases
Statistical review of association between clinicopathologic parameters
Assessment of the relationship between CHFR protein and mRNA levels and association between this relationship and promoter methylation of the CHFR gene in 20 frozen sections of NSCLC
Results
Overexpression of Aurora-A and reduced expression of CHFR in 94 cases (59.8%) and 62 cases (39%) of NSCLC, respectively; significantly correlated with tumor differentiation and size
Diminished CHFR expression significantly associated with smoking-related squamous cell carcinoma cases and poor prognosis
Multivariate analysis showed CHFR expression as an independent prognostic factor
Statistical correlation found between CHFR protein and mRNA expression
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