Yano T et al. - The differences in the clinicopathologic factors and survivals between the never-smoking nonsmall cell lung cancer (NSCLC) patient group and the smoking NSCLC group suggest that NSCLC in never-smokers should be considered a separate disease entity. Methods
Aim was to propose never-smoking NSCLC as a separate entity
Clinicopathologic differences of operable NSCLC between never-smoking pts and pts with a history of smoking were investigated
Medical records of 1405 pts with primary NSCLC who underwent a complete resection were reviewed for clinicopathologic variables and postoperative survival
Results
The proportion of never-smoking pts with NSCLC has been increasing over 30 yrs
A greater proportion of female pts or adenocarcinoma pts was found in the never-smoking NSCLC group in comparison to the smoking NSCLC group
The proportion of pathologic stage IA disease for the never-smoking NSCLC group was higher than that for the smoking NSCLC group
With regard to both overall and cancer-specific survival, the never-smoking NSCLC patient group was superior to the smoking NSCLC group
Other factors associated with the postoperative survival rate were sex, histologic type, T classification, and N classification
Never-smoking status was an independent prognostic factor in addition to pathologic T and N classification
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