Flynn JR et al. - In a study to examine 4 markers of hypoxia and compare them with the overall survival (OS) rates of adults with glioblastoma multiforme (GBM), it was shown that tumor grade was differentiated with hypoxia-regulated molecules (HRMs), microvascular density (MVD), and proliferation, but only glucose transporter 1 (GLUT-1) predicted survival in these pts with GBM Methods
Pts who had lower grade astrocytomas were compared with pts who had GBM to verify that the methods used could establish differences between tumor grades
By using preoperative imaging, the amount of necrosis was established vs the overall tumor area
Preoperative images were compared with postoperative images to define the amount of tumor resected; and compared molecular markers, proliferation, MVD, and imaging studies with survival among pts who had GBM
Results
HRMs and indices for MVD and cellular proliferation were associated significantly with tumor grade
Survival was improved when 95% of the tumor was resected
Although the total tumor area was associated with OS, no differences were observed when the amount of necrosis or a tumor necrosis index was compared with survival
Findings indicated that GLUT-1 and VEGF were correlated with survival after controlling for age
See all
