hemeonclinx Medical News about polycythemia vera; essential thrombocythemia; JAK2 V617F mutation; platelet function

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Megakaryopoiesis and platelet function in polycythemia vera and essential thrombocythemia patients with JAK2 V617F mutation
International Journal of Hematology, 07/14/08

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Free Abstract

Hattori N et al. - The authors found a hypercoagulable state in Ph-CMPD with V617F by employing whole blood thromboelastography. It suggests pre-thrombotic tendencies in CMPD are complex and JAK2 V617F mutation might have a role in vivo blood coagulation by altering not only the number, but function(s) of all three myeloid cells, including red blood cells, white blood cells and platelets in Ph-CMPD.

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