Higuchi I et al. – Posttreatment PET-FDG reliably predicted histologic response and postoperative survival in advanced esophageal squamous cell carcinoma, which may be used to tailor optimal treatment based on individual responses Methods
Study of PET-FDG in assessment of response of advanced esophageal squamous cell carcinoma to neoadjuvant treatment to establish new criteria to predict postoperative long-term survival
PET-FDG before surgical resection in 50 pts with locally advanced esophageal squamous cell carcinoma who had neoadjuvant therapy (chemotherapy, 35 pts; chemoradiotherapy, 15)
Evaluation of posttreatment maximum SUV, residual tumor size (maximum square area of longitudinal axis), histologic response, and postoperative survival
Results
After treatment, uptake was NOT noted in 21 pts (posttreatment maximum SUV <2.5, negative) but was detected in 29 (≥2.5, positive)
Residual tumor size: 0-54 mm2, negative results; 55-676 mm2, positive; clearly distinguished histologic major response from nonresponse
5-yr cause-specific survival: significantly higher in negative (67.7%) vs positive grp (36.5%)
Hematogenous recurrence: significantly lower in negative (4.8%) vs positive grp (37%)
On univariate Cox regression analyses, posttreatment maximum SUV (cutoff 2.5) was the only preoperative prognostic factor
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