Fall K et al. - Data presented in this study do not support an association between carriage of the variant IRS-1 gene and prostate cancer risk. Methods
Aim was to assess the influence of the most common IRS-1 gene polymorphism (Gly972Arg) on prostate cancer risk, alone and in combination with IGF-1
IRS-1 polymorphism was assayed in 564 incident prostate cancer cases and 758 controls matched on age and smoking
Relative risks (RR) and 95% confidence intervals (CI) using conditional logistic regression
Results
0.8% were homozygous (AA) and 12% were heterozygous (GA) for the polymorphic allele
No association between carriage of the A allele and total prostate cancer risk, advanced disease, or plasma IGF-1 levels
Possible interactions with BMI and components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN was explored
However, none of these factors influenced the relation between IRS-1 genotype and prostate cancer risk
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