Yanga W et al. - Integrated PET/CT improves the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value than enhanced CT in the assessment of locoregional lymph nodes, and provides more efficient and accurate data of nodal staging, with a better effect on diagnosis and therapy in non-small cell lung cancer. Methods
Study to compare the diagnostic efficacies of integrated 18F FDG PET/CT images and contrast-enhanced helical CT images in locoregional lymph node metastasis in NSCLC pts
122 pts with proven or suspected NSVLC underwent integrated PET/CT and contrast-enhanced CT scans followed by surgical nodal staging
The results were compared in relation to pathologic findings
Results
Preoperative nodal staging was compared with postoperative histopathological staging
80% of pts correctly staged, 13% were overstaged, and 7% were understaged by PET/CT
While those values for CT were 56%, 26%, and 18% respectively
The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of PET/CT for lymph nodes were 86%, 85%, 85%, 64%, 95%, respectively vs 69%, 71%, 70%, 43%, 88% for CT
81% false-negative interpretations and 72% false-positive interpretations on CT were corrected by PET/CT
57% false-negative interpretations and 45% false-positive interpretations on PET/CT were corrected by CT
6% positive lymph nodes and 8% of negative nodes at pathology were incorrectly diagnosed both by PET/CT and CT
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