Yamamoto S et al. - Clear-cell adenofibroma (CCAF) can be a clonal precursor for ovarian clear-cell adenocarcinoma. Methods
Study to examine the genetic linkage between CCAF and CCA of the ovary
Allelotype analysis for both CCAF and adjacent CCA components was conducted in 14 cases
DNA isolated from laser-microdissected tissue was subjected to PCR and analysis for loss of heterozygosity (LOH)
17 polymorphic markers located on 11 chromosomal arms were used
Results
For all informative loci, the frequency of LOH in adenocarcinoma was 49% and was higher than the components of benign CCAF and borderline CCAF
Between CCAF and adenocarcinoma components, an identical LOH pattern, involving the same alleles, was found in 93% of cases at one or more chromosomal loci
Among the markers examined, LOHs on 5q, 10q and 22q were frequent in both CCAF and adenocarcinoma components
LOHs on 1p and 13q were rare in CCAF components but frequent in adenocarcinoma components
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