Chang HC et al. - Dihydrodiol dehydrogenase (DDH) expression may be useful in identifying high-risk gastric cancer patients and distinguishing future candidates for curative and palliative treatment. Methods
Study to evaluate the (i) correlation between clinicopathological data and DDH expression and (ii) the prognostic significance of DDH expression in pts with resected gastric cancer
81 pts who received surgical treatment for gastric cancer were enrolled
Pathology samples were immunostained with monoclonal antibody to DDH
The relationship between DDH expression and clinicopathological data was analyzed by chi-square analysis
Survival curves were plotted using the Kaplan–Meier method and compared using a log-rank test
Results
The overexpression rate of DDH was 41.9%
Of pts with overexpressed DDH, 13% had stage I, 24% had stage II, 52% had stage III, and 78% had stage IV tumors
Among pts who died, DDH expression level differed between high and low-expression groups
Survival was better in pts with low DDH expression
See all
