Muller CI et al. – A high degree of microsatellite instability (MSI-H) incidence in metastatic colorectal cancer (CRC) was low; MSI-H may correlate with a poorer response to a 5-FU/oxaliplatin treatment, pending confirmation in a larger cohort Methods
Study of the incidence and prognostic value of MSI-H in 108 metastatic CRC pts treated in a prospective, randomized trial comparing 2 oxaliplatin and 5-FU-based therapy regimens (FUFOX vs CAPOX)
PCR analysis specimens by NIH reference panel
Immunostaining of mismatch repair proteins MLH1, MSH2 and MSH6
Results
Incidence of MSI-H: 4%
MSI-H correlated with a lower rate of disease in control vs non-MSI-H pts
No correlation noted between MSI-H and progression-free survival or overall survival
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