Amos C et al. - In a study to explore 2 single-nucleotide polymorphisms (SNPs) on chromosome 15, it was found that these SNPs are associated with an increased likelihood of developing lung cancer Methods
A series of genome-wide association studies were conducted to look for common genotype variations that might be associated with lung cancer
315,450 SNPs were analyzed in 1154 current and former smokers who had lung cancer and a control group of 1137 ever-smokers who did not get the disease, matching cases with controls according to smoking behavior, age, and number of years since cessation
10 of the most significant genetic associations found were then replicated in 2 additional case-control datasets: 1 from the same group in Texas (711 cases and 632 controls) and the other the United Kingdom (2012 cases and 3062 controls)
Results
In both replications, there was an increased risk associated with 2 specific SNPs, rs10151730 and rs8034191, both mapping to an 88-kb region on chromosome 15
The 2 SNPs identified were very close together and tended to be similar in individuals
Individuals who smoked and had 1 or 2 of these specific SNPs were at a 28% to 81% increased risk of developing lung cancer, an indicator that held regardless of degree of dependence and number of years smoked
See all
