hemeonclinx Medical News about Head and Neck Cancer; bortezomib; noncanonical NF-kappaB

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Allen C et al. - Although low-dose bortezomib inhibits activation of subunits of the canonical pathway, it does not block nuclear activation of the noncanonical NF-kappaB or other prosurvival signal pathways, which may contribute to the heterogeneous responses observed in HNSCC.

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